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We investigate the pathogenesis of infectious diseases, with a focus on bacterial diseases affecting children. Using a variety of techniques, we are currently attempting to answer questions in three main areas:
Bacterial colonization and host range
The mucosal surfaces of humans are simultaneously colonized with a vast number of microbial species, some of which are potential pathogens. Certain members of this microbiota may colonize or infect multiple host species, while others are host-specific. What specific bacterial and host products are essential to host range in the settings of colonization and disease?
Evolution and function of bacterial toxins
Many bacterial pathogens of humans produce protein toxins that damage or kill host cells at high concentrations. However, it is advantageous for the host to recognize these products while they are at low density and to initiate immune responses before lethal toxin concentrations are present. How do host cells detect and respond to sublethal concentrations of bacterial toxins? How can we most efficiently identify and characterize new toxins and understand their evolution?
Infectious causes of preterm birth
Premature birth is a major cause of pediatric morbidity and mortality worldwide, but its causes are poorly understood. Several infectious diseases, including bacterial vaginosis, urinary tract infection, and chorioamnionitis, increase the risk of premature birth. We are attempting to model these conditions in an effort to better understand the link between infection and prematurity and to develop and evaluate targeted diagnostics and interventions.
